ELECTROCHEMICAL DETECTION

GeneFluidics' direct detection module measures health-specific and disease-specific biomolecules (DNAs, RNAs, proteins, and ions) in raw samples with ultra-high non-target amplified sensitivity. Sub-femtomolar (genetic material) and sub-pg/mL (protein) sensitivities are made possible by taking advantage of high turnover enzyme cycling. Cycling occurs when an enzyme is immobilized onto our sensors via an anchor probe/target/signal probe hybrid, substrate solution introduced, and a control bias potential applied at the sensor surface. Because of the short diffusion length (few tenths of a nanometer) between the immobilized enzymes and the sensor, the electron turnover from the corresponding redox reaction is such that over 20,000 electrons are transferred per enzyme per second. This enables a signal to be measured with just a few targets present.

A second factor driving sensitivity is GeneFluidics' exceptionally uniform nanoscale Self Assembled Monolayer ("SAM") (enabled by optical grade sensor flatness), which not only blocks non-specific binding of cellular debris, but also ensures a uniform anchor probe attachment for consistent readings. The SAM also acts as a filter that allows only our specific redox reactant to pass through the molecular matrices.

GeneFluidics' manual detection products are currently available for purchase directly or through Fisher Scientific.

Latest News:

Sept 12, 2007 GeneFluidics is funded to advance the rapid antibiotics resistance screening test with VA/UCLA hospital and ASU

Jan 1, 2007 Saliva diagnostics made possible with GeneFluidics' technology

Non-Invasive Health Screening with Saliva

October 17, 2006 GeneFluidics is awarded to advance saliva diagnostics through a $15 Million NIH project.

February 2, 2006 UCLA / VA study demonstrates the rapid diagnosis of Urinary Track Infections with novel biosensor technology

UTI Video Release (High Resolution)

August 8, 2005 GeneFluidics, Inc. Announces Collaboration with the Shanghai Institute of Applied Physics, Chinese Academy of Sciences